Version 5.4
Homo sapiens Protein: SNTG2
Summary
InnateDB Protein IDBP-292637.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SNTG2
Protein Name syntrophin, gamma 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000385020
InnateDB Gene IDBG-25486 (SNTG2)
Protein Structure
UniProt Annotation
Function Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane.
Disease Associations
Tissue Specificity Widely expressed. Strong expression in brain and testis. In CNS, it is expressed in the perikaryon and proximal portion of the neuronal processes. Strong expression in the hippocampus, neuron-rich dendate granule cells, and pyramidal cell layers. Highly expressed in neurons of the cerebral cortex. Also expressed in the cerebellar cortex, deep cerebellar nuclei, thalamus, and basal ganglia. {ECO:0000269PubMed:10747910}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0030165 PDZ domain binding
Biological Process
GO:0007417 central nervous system development
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0016013 syntrophin complex
GO:0042383 sarcolemma
Protein Structure and Domains
PDB ID
InterPro IPR001849 Pleckstrin homology domain
PFAM PF00169
PRINTS
PIRSF
SMART SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NY99
PhosphoSite PhosphoSite-Q9NY99
TrEMBL
UniProt Splice Variant
Entrez Gene 54221
UniGene Hs.595069
RefSeq
HUGO HGNC:13741
OMIM 608715
CCDS
HPRD 16374
IMGT
EMBL AC108462 AC114808 AC116614 AC140476 AC144444 AC144527 AC225604 AJ003029 BC125251
GenPept AAI25252 CAB92969

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca