InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GGT2

Summary

InnateDB Protein

IDBP-292655.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GGT2

Protein Name

gamma-glutamyltransferase 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000385721

InnateDB Gene

IDBG-1970 (GGT2)

Protein Structure

UniProt Annotation

Function

Isoform 1, isoform 2 and isoform 3 lack catalytic activity due to its inability to undergo the autocatalytic cleavage needed to produce a mature, enzymatically active heterodimer. {ECO:0000269PubMed:23682772}.

Subcellular Localization

Cytoplasm, perinuclear region {ECO:0000269PubMed:23682772}. Endoplasmic reticulum {ECO:0000269PubMed:23682772}. Note=Co-localizes with calnexin in the endoplasmic reticulum.

Disease Associations

Tissue Specificity

Highly expressed in fetal and adult kidney and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003840	gamma-glutamyltransferase activity

Biological Process

GO:0006749	glutathione metabolic process
GO:0006750	glutathione biosynthetic process
GO:0006805	xenobiotic metabolic process
GO:0019370	leukotriene biosynthetic process
GO:0044281	small molecule metabolic process
GO:1901687	glutathione derivative biosynthetic process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0031362	anchored component of external side of plasma membrane
GO:0048471	perinuclear region of cytoplasm