InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: C1GALT1

Summary

InnateDB Protein

IDBP-292761.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

C1GALT1

Protein Name

core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000384550

InnateDB Gene

IDBG-8487 (C1GALT1)

Protein Structure

UniProt Annotation

Function

Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development.

Subcellular Localization

Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. Highly expressed in kidney, heart, placenta and liver. {ECO:0000269PubMed:11677243}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008378	galactosyltransferase activity
GO:0016263	glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity
GO:0016757	transferase activity, transferring glycosyl groups
GO:0046872	metal ion binding

Biological Process

GO:0001525	angiogenesis
GO:0001822	kidney development
GO:0006486	protein glycosylation
GO:0016266	O-glycan processing
GO:0030154	cell differentiation
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process