InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ICA1

Summary

InnateDB Protein

IDBP-292778.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ICA1

Protein Name

islet cell autoantigen 1, 69kDa

Synonyms

ICA69; ICAp69;

Species

Homo sapiens

Ensembl Protein

ENSP00000385651

InnateDB Gene

IDBG-8551 (ICA1)

Protein Structure

UniProt Annotation

Function

May play a role in neurotransmitter secretion. {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:12682071}. Golgi apparatus membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Predominantly cytosolic. Also exists as a membrane-bound form which has been found associated with synaptic vesicles and also with the Golgi complex and immature secretory granules.

Disease Associations

Tissue Specificity

Expressed abundantly in pancreas, heart and brain with low levels of expression in lung, kidney, liver and thyroid.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0019904	protein domain specific binding

Biological Process

GO:0006836

neurotransmitter transport

Cellular Component

GO:0000139	Golgi membrane
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0030054	cell junction
GO:0030658	transport vesicle membrane
GO:0030667	secretory granule membrane
GO:0030672	synaptic vesicle membrane