InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ROCK2

Summary

InnateDB Protein

IDBP-292790.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ROCK2

Protein Name

Rho-associated, coiled-coil containing protein kinase 2

Synonyms

ROCK-II;

Species

Homo sapiens

Ensembl Protein

ENSP00000385509

InnateDB Gene

IDBG-29657 (ROCK2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017048	Rho GTPase binding
GO:0046872	metal ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0035556	intracellular signal transduction

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001849 Pleckstrin homology domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR010978 tRNA-binding arm
IPR011009 Protein kinase-like domain
IPR015008 Rho binding domain
IPR017892 Protein kinase, C-terminal

PFAM

PF00069
PF00169
PF00130
PF08912
PF00433

PRINTS

PIRSF

SMART

SM00133
SM00233
SM00109
SM00220

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite