Version 5.4
Homo sapiens Protein: SH3BP5
Summary
InnateDB Protein IDBP-292791.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SH3BP5
Protein Name SH3-domain binding protein 5 (BTK-associated)
Synonyms SAB; SH3BP-5;
Species Homo sapiens
Ensembl Protein ENSP00000386231
InnateDB Gene IDBG-20659 (SH3BP5)
Protein Structure
UniProt Annotation
Function Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. {ECO:0000269PubMed:10339589, ECO:0000269PubMed:9571151}.
Subcellular Localization Mitochondrion {ECO:0000269PubMed:12167088}.
Disease Associations
Tissue Specificity Highly expressed in testis and ovaries. It is also expressed in a variety of tissues including spleen, lymph node, thymus, bone marrow, fetal liver, colon, small intestine and prostate. {ECO:0000269PubMed:9571151}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004860 protein kinase inhibitor activity
GO:0005515 protein binding
GO:0017124 SH3 domain binding
Biological Process
GO:0007165 signal transduction
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID
InterPro IPR007940 SH3-binding 5
PFAM PF05276
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O60239
PhosphoSite PhosphoSite-O60239
TrEMBL Q6MZG3
UniProt Splice Variant
Entrez Gene 9467
UniGene Hs.257761
RefSeq NP_001018009
HUGO HGNC:10827
OMIM 605612
CCDS CCDS43055
HPRD 12030
IMGT
EMBL AB005047 AC087590 AK090524 AL117422 BC010123 BX641159 CH471055
GenPept AAH10123 BAA25922 BAG52178 CAE46071 CAI46220 EAW64225 EAW64228

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca