InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GIGYF2

Summary

InnateDB Protein

IDBP-292888.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GIGYF2

Protein Name

GRB10 interacting GYF protein 2

Synonyms

GYF2; PARK11; PERQ2; PERQ3; TNRC15;

Species

Homo sapiens

Ensembl Protein

ENSP00000387170

InnateDB Gene

IDBG-83337 (GIGYF2)

Protein Structure

UniProt Annotation

Function

May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors. {ECO:0000269PubMed:12771153}.

Subcellular Localization

Disease Associations

Parkinson disease 11 (PARK11) [MIM:607688]: A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. {ECO:0000269PubMed:18358451}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	55 [view]
Protein-Protein	55 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0007631	feeding behavior
GO:0008219	cell death
GO:0008344	adult locomotory behavior
GO:0009791	post-embryonic development
GO:0017148	negative regulation of translation
GO:0021522	spinal cord motor neuron differentiation
GO:0031571	mitotic G1 DNA damage checkpoint
GO:0035264	multicellular organism growth
GO:0044267	cellular protein metabolic process
GO:0048009	insulin-like growth factor receptor signaling pathway
GO:0048873	homeostasis of number of cells within a tissue
GO:0050881	musculoskeletal movement
GO:0050885	neuromuscular process controlling balance