Version 5.4
Homo sapiens Gene: GIGYF2
Summary
InnateDB Gene IDBG-83337.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GIGYF2
Gene Name GRB10 interacting GYF protein 2
Synonyms GYF2; PARK11; PERQ2; PERQ3; TNRC15
Species Homo sapiens
Ensembl Gene ENSG00000204120
Encoded Proteins
IDBP-83341
GRB10 interacting GYF protein 2
IDBP-292899
GRB10 interacting GYF protein 2
IDBP-292901
GRB10 interacting GYF protein 2
IDBP-292887
GRB10 interacting GYF protein 2
IDBP-292888
GRB10 interacting GYF protein 2
IDBP-292889
GRB10 interacting GYF protein 2
IDBP-389322
GRB10 interacting GYF protein 2
IDBP-389323
GRB10 interacting GYF protein 2
IDBP-389324
GRB10 interacting GYF protein 2
IDBP-389325
GRB10 interacting GYF protein 2
IDBP-389326
GRB10 interacting GYF protein 2
IDBP-389327
GRB10 interacting GYF protein 2
IDBP-389328
GRB10 interacting GYF protein 2
IDBP-389329
GRB10 interacting GYF protein 2
IDBP-389330
GRB10 interacting GYF protein 2
IDBP-389331
GRB10 interacting GYF protein 2
IDBP-389334
GRB10 interacting GYF protein 2
IDBP-389335
GRB10 interacting GYF protein 2
IDBP-389337
GRB10 interacting GYF protein 2
IDBP-389338
GRB10 interacting GYF protein 2
IDBP-389339
GRB10 interacting GYF protein 2
IDBP-389341
GRB10 interacting GYF protein 2
IDBP-389342
GRB10 interacting GYF protein 2
IDBP-389343
GRB10 interacting GYF protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene interacts with GRB10 and may be involved in the regulation of tyrosine kinase receptor signaling. This gene contains CAG repeats, and the encoded protein contains stretches glutamine and glutamic acid residues. Defects in this gene are a cause of Parkinson disease type 11 (PARK11). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
This gene contains CAG trinucleotide repeats and encodes a protein containing several stretches of polyglutamine residues. The encoded protein may be involved in the regulation of tyrosine kinase receptor signaling. This gene is located in a chromosomal region that was genetically linked to Parkinson disease type 11, and mutations in this gene were thought to be causative for this disease. However, more recent studies in different populations have been unable to replicate this association. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:232697299-232858627
Strand Forward strand
Band q37.1
Transcripts
ENST00000373563 ENSP00000362664
ENST00000409480 ENSP00000386765
ENST00000409547 ENSP00000386537
ENST00000409196 ENSP00000387070
ENST00000409451 ENSP00000387170
ENST00000410033 ENSP00000387276
ENST00000427233 ENSP00000396590
ENST00000428883 ENSP00000402712
ENST00000456491 ENSP00000413612
ENST00000430720 ENSP00000396958
ENST00000425040 ENSP00000407161
ENST00000421433 ENSP00000402053
ENST00000423659 ENSP00000404195
ENST00000440945 ENSP00000410297
ENST00000429187 ENSP00000392991
ENST00000424038 ENSP00000399064
ENST00000424414 ENSP00000401261
ENST00000445650 ENSP00000392218
ENST00000436349 ENSP00000400076
ENST00000421778 ENSP00000390325
ENST00000455139 ENSP00000395299
ENST00000427649 ENSP00000398055
ENST00000458528 ENSP00000389322
ENST00000426102 ENSP00000415037
ENST00000476995
ENST00000484409
ENST00000492910
ENST00000475359
ENST00000488629
ENST00000490612
ENST00000464402
ENST00000488734
ENST00000474465
ENST00000463554
ENST00000482666
ENST00000490229
ENST00000483164
ENST00000464805
ENST00000489328
ENST00000473170
ENST00000475530
ENST00000482952
ENST00000474312
ENST00000469843
ENST00000471011
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 55 [view]
Protein-Protein 55 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0007631 feeding behavior
GO:0008219 cell death
GO:0008344 adult locomotory behavior
GO:0009791 post-embryonic development
GO:0017148 negative regulation of translation
GO:0021522 spinal cord motor neuron differentiation
GO:0031571 mitotic G1 DNA damage checkpoint
GO:0035264 multicellular organism growth
GO:0044267 cellular protein metabolic process
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0048873 homeostasis of number of cells within a tissue
GO:0050881 musculoskeletal movement
GO:0050885 neuromuscular process controlling balance
Cellular Component
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000048000
View Gene Order
ENSBTAG00000014079
Not yet available
Cross-References
SwissProt Q6Y7W6
TrEMBL A0A024R4A5 B8ZZD2 C9IYH5 C9J0V6 C9J1A6 C9J7G1 C9JH18 C9JH78 C9JHT0 C9JHW1 C9JPV7 C9JRZ2 C9JW88 C9JXQ0 C9JZC0 E7ESB6 F8WBF1 F8WCD5 I1E4Y6
UniProt Splice Variant
Entrez Gene 26058
UniGene Hs.435841 Hs.626328
RefSeq NM_001103146 NM_001103147 NM_001103148 NM_015575
HUGO HGNC:11960
OMIM 612003
CCDS CCDS33401 CCDS46542 CCDS46543
HPRD
IMGT
EMBL AB014542 AC016692 AC064852 AK001739 AY176045 BC008072 BC136251 BC146775 BX537885 BX538172 BX538321 CH471063
GenPept AAH08072 AAI36252 AAI46776 AAO46889 BAA31617 BAA91873 CAD97881 CAD98095 EAW71016 EAW71018
RNA Seq Atlas 26058

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca