InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NGEF

Summary

InnateDB Protein

IDBP-292891.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NGEF

Protein Name

neuronal guanine nucleotide exchange factor

Synonyms

ARHGEF27; EPHEXIN;

Species

Homo sapiens

Ensembl Protein

ENSP00000387033

InnateDB Gene

IDBG-83399 (NGEF)

Protein Structure

UniProt Annotation

Function

Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Note=Associated with membranes. Localizes to axonal growth cones (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in brain specifically in caudate nucleus and to a lower extent in amygdala and hippocampus. Also detected in lung. {ECO:0000269PubMed:10777665}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0043087	regulation of GTPase activity
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048013	ephrin receptor signaling pathway
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0061002	negative regulation of dendritic spine morphogenesis
GO:0097190	apoptotic signaling pathway