Version 5.4
Homo sapiens Protein: GIGYF2
Summary
InnateDB Protein IDBP-292901.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GIGYF2
Protein Name GRB10 interacting GYF protein 2
Synonyms GYF2; PARK11; PERQ2; PERQ3; TNRC15;
Species Homo sapiens
Ensembl Protein ENSP00000386537
InnateDB Gene IDBG-83337 (GIGYF2)
Protein Structure
UniProt Annotation
Function May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors. {ECO:0000269PubMed:12771153}.
Subcellular Localization
Disease Associations Parkinson disease 11 (PARK11) [MIM:607688]: A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. {ECO:0000269PubMed:18358451}. Note=The disease may be caused by mutations affecting the gene represented in this entry.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 55 [view]
Protein-Protein 55 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0008219 cell death
GO:0017148 negative regulation of translation
Cellular Component
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR003169 GYF
PFAM PF02213
PRINTS
PIRSF
SMART SM00444
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6Y7W6
PhosphoSite PhosphoSite-Q6Y7W6
TrEMBL C9JZC0
UniProt Splice Variant
Entrez Gene 26058
UniGene Hs.626328
RefSeq NP_056390
HUGO HGNC:11960
OMIM 612003
CCDS CCDS33401
HPRD 11639
IMGT
EMBL AB014542 AC016692 AC064852 AK001739 AY176045 BC008072 BC136251 BC146775 BX537885 BX538172 BX538321 CH471063
GenPept AAH08072 AAI36252 AAI46776 AAO46889 BAA31617 BAA91873 CAD97881 CAD98095 EAW71016 EAW71018

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca