Version 5.4
Homo sapiens Protein: SIRT1
Summary
InnateDB Protein IDBP-292930.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIRT1
Protein Name sirtuin 1
Synonyms SIR2L1;
Species Homo sapiens
Ensembl Protein ENSP00000384063
InnateDB Gene IDBG-75847 (SIRT1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 383 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.
Experimentally validated
Total 383 [view]
Protein-Protein 268 [view]
Protein-DNA 6 [view]
Protein-RNA 1 [view]
DNA-DNA 108 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 47 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0070403 NAD+ binding
Biological Process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR003000 Sirtuin family
IPR026590 Sirtuin family, catalytic core domain
IPR029035 DHS-like NAD/FAD-binding domain
PFAM PF02146
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL B0QZ35
UniProt Splice Variant
Entrez Gene 23411
UniGene Hs.369779
RefSeq
HUGO HGNC:14929
OMIM 604479
CCDS
HPRD 08381
IMGT
EMBL AK074805 AL133551
GenPept BAG52006

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca