InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CAB39

Summary

InnateDB Protein

IDBP-292936.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CAB39

Protein Name

calcium binding protein 39

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000386642

InnateDB Gene

IDBG-82966 (CAB39)

Protein Structure

UniProt Annotation

Function

Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1. {ECO:0000269PubMed:19892943}.

Subcellular Localization

Cytoplasm {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.

Experimentally validated
Total	23 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004674	protein serine/threonine kinase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0019900	kinase binding
GO:0030295	protein kinase activator activity
GO:0043539	protein serine/threonine kinase activator activity

Biological Process

GO:0007050	cell cycle arrest
GO:0008286	insulin receptor signaling pathway
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0023014	signal transduction by phosphorylation
GO:0035556	intracellular signal transduction
GO:0071476	cellular hypotonic response
GO:0071902	positive regulation of protein serine/threonine kinase activity
GO:1901017	negative regulation of potassium ion transmembrane transporter activity
GO:1901380	negative regulation of potassium ion transmembrane transport
GO:2000681	negative regulation of rubidium ion transport
GO:2000687	negative regulation of rubidium ion transmembrane transporter activity