InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SP100

Summary

InnateDB Protein

IDBP-292941.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SP100

Protein Name

SP100 nuclear antigen

Synonyms

lysp100b;

Species

Homo sapiens

Ensembl Protein

ENSP00000386404

InnateDB Gene

IDBG-82951 (SP100)

Protein Structure

UniProt Annotation

Function

Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53- mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. {ECO:0000269PubMed:11909962, ECO:0000269PubMed:14647468, ECO:0000269PubMed:15247905, ECO:0000269PubMed:15592518, ECO:0000269PubMed:15767676, ECO:0000269PubMed:16177824, ECO:0000269PubMed:17245429, ECO:0000269PubMed:21118961, ECO:0000269PubMed:21274506, ECO:0000269PubMed:21880768}.

Subcellular Localization

Nucleus. Nucleus, PML body. Cytoplasm. Note=Differences in the subnuclear localization of the different isoforms seem to exist and may also be cell cycle- and interferon- dependent. Accumulates in the cytoplasm upon FAS activation.Isoform Sp100-C: Nucleus {ECO:0000269PubMed:11313457}. Note=Forms a reticulate or track- like nuclear pattern with denser concentrations at the nuclear lamina and surrounding the nucleoli, a pattern reminiscent of heterochromatin-rich regions according to PubMed:11313457.

Disease Associations

Tissue Specificity

Widely expressed. Sp100-B is expressed only in spleen, tonsil, thymus, mature B-cell line and some T-cell line, but not in brain, liver, muscle or non-lymphoid cell lines.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.

Experimentally validated
Total	56 [view]
Protein-Protein	54 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019900	kinase binding
GO:0019904	protein domain specific binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0070087	chromo shadow domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000723	telomere maintenance
GO:0006351	transcription, DNA-templated
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0010596	negative regulation of endothelial cell migration
GO:0016032	viral process
GO:0019221	cytokine-mediated signaling pathway
GO:0032526	response to retinoic acid
GO:0032897	negative regulation of viral transcription
GO:0034097	response to cytokine
GO:0034340	response to type I interferon
GO:0034341	response to interferon-gamma
GO:0043392	negative regulation of DNA binding
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045765	regulation of angiogenesis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046826	negative regulation of protein export from nucleus
GO:0048384	retinoic acid receptor signaling pathway
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051271	negative regulation of cellular component movement
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0060337	type I interferon signaling pathway
GO:1902041	regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902044	regulation of Fas signaling pathway