InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCL20

Summary

InnateDB Protein

IDBP-292952.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCL20

Protein Name

chemokine (C-C motif) ligand 20

Synonyms

CKb4; Exodus; LARC; MIP-3-alpha; MIP-3a; MIP3A; SCYA20; ST38;

Species

Homo sapiens

Ensembl Protein

ENSP00000386273

InnateDB Gene

IDBG-82684 (CCL20)

Protein Structure

UniProt Annotation

Function

Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E.coli ATCC 25922 and S.aureus ATCC 29213. {ECO:0000269PubMed:12149255}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and fetal lung. Low levels seen in thymus, prostate, testis, small intestine and colon.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	13 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008009	chemokine activity

Biological Process

GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0042742	defense response to bacterium
GO:0060326	cell chemotaxis
GO:2000406	positive regulation of T cell migration