InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CCL20

Summary

InnateDB Gene

IDBG-82684.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCL20

Gene Name

chemokine (C-C motif) ligand 20

Synonyms

CKb4; Exodus; LARC; MIP-3-alpha; MIP-3a; MIP3A; SCYA20; ST38

Species

Homo sapiens

Ensembl Gene

ENSG00000115009

Encoded Proteins

IDBP-82686

chemokine (C-C motif) ligand 20

IDBP-292952

chemokine (C-C motif) ligand 20

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene displays chemotactic activity for lymphocytes and can repress proliferation of myeloid progenitors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:227813842-227817564

Strand

Forward strand

Band

q36.3

Transcripts

ENST00000358813	ENSP00000351671
ENST00000409189	ENSP00000386273
ENST00000489160
ENST00000473642

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	13 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008009	chemokine activity

Biological Process

GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0042060	wound healing
GO:0042742	defense response to bacterium
GO:0050726	positive regulation of interleukin-1 alpha biosynthetic process
GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process
GO:0060326	cell chemotaxis
GO:0071222	cellular response to lipopolysaccharide
GO:0071223	cellular response to lipoteichoic acid
GO:0071310	cellular response to organic substance
GO:2000406	positive regulation of T cell migration

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000026166

View Gene Order

Pathways

NETPATH

REACTOME

REACT_19231

G alpha (i) signalling events pathway

REACT_15344

Chemokine receptors bind chemokines pathway

REACT_14819

Peptide ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04062

Chemokine signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.75498

RefSeq

NM_001130046 NM_004591

HUGO

OMIM

CCDS

CCDS2469 CCDS46536

HPRD

03571

IMGT

EMBL

GenPept

RNA Seq Atlas