InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MFF

Summary

InnateDB Protein

IDBP-292962.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MFF

Protein Name

mitochondrial fission factor

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000386964

InnateDB Gene

IDBG-82567 (MFF)

Protein Structure

UniProt Annotation

Function

Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles. {ECO:0000269PubMed:18353969, ECO:0000269PubMed:23530241}.

Subcellular Localization

Mitochondrion outer membrane; Single-pass type IV membrane protein. Peroxisome. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in heart, kidney, liver, brain, muscle, and stomach. {ECO:0000269PubMed:18353969}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000266	mitochondrial fission
GO:0001836	release of cytochrome c from mitochondria
GO:0006626	protein targeting to mitochondrion
GO:0008053	mitochondrial fusion
GO:0010821	regulation of mitochondrion organization
GO:0016559	peroxisome fission
GO:0043653	mitochondrial fragmentation involved in apoptotic process
GO:0051260	protein homooligomerization
GO:0070584	mitochondrion morphogenesis
GO:0090141	positive regulation of mitochondrial fission
GO:0090200	positive regulation of release of cytochrome c from mitochondria
GO:0090314	positive regulation of protein targeting to membrane
GO:1900063	regulation of peroxisome organization

Cellular Component

GO:0005741	mitochondrial outer membrane
GO:0005777	peroxisome
GO:0008021	synaptic vesicle
GO:0030054	cell junction
GO:0032592	integral component of mitochondrial membrane