Version 5.4
Homo sapiens Gene: MFF
Summary
InnateDB Gene IDBG-82567.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MFF
Gene Name mitochondrial fission factor
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000168958
Encoded Proteins
IDBP-82569
mitochondrial fission factor
IDBP-82571
mitochondrial fission factor
IDBP-82573
mitochondrial fission factor
IDBP-82575
mitochondrial fission factor
IDBP-82577
mitochondrial fission factor
IDBP-246430
mitochondrial fission factor
IDBP-292962
mitochondrial fission factor
IDBP-292963
mitochondrial fission factor
IDBP-389168
mitochondrial fission factor
IDBP-389170
mitochondrial fission factor
IDBP-389173
mitochondrial fission factor
IDBP-389174
mitochondrial fission factor
IDBP-389175
mitochondrial fission factor
IDBP-389177
mitochondrial fission factor
IDBP-596899
mitochondrial fission factor
IDBP-599591
mitochondrial fission factor
IDBP-600235
mitochondrial fission factor
IDBP-600497
mitochondrial fission factor
IDBP-597667
mitochondrial fission factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 24733894
Hepatitis C infection stimulates the expression of DNM1L and MFF and promotes DNM1L recruitment to mitochondria by stimulating the phosphorylation of DNM1L, leading to mitochondrial fission.
Entrez Gene
Summary This is a nuclear gene encoding a protein that functions in mitochondrial and peroxisomal fission. The encoded protein recruits dynamin-1-like protein (DNM1L) to mitochondria. There are multiple pseudogenes for this gene on chromosomes 1, 5, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:227325151-227357836
Strand Forward strand
Band q36.3
Transcripts
ENST00000337110 ENSP00000338412
ENST00000354503 ENSP00000346498
ENST00000349901 ENSP00000304134
ENST00000304593 ENSP00000304898
ENST00000353339 ENSP00000302037
ENST00000392059 ENSP00000375912
ENST00000409565 ENSP00000386964
ENST00000409616 ENSP00000386641
ENST00000423098 ENSP00000390165
ENST00000452930 ENSP00000415996
ENST00000436237 ENSP00000411386
ENST00000443428 ENSP00000391829
ENST00000418961 ENSP00000407547
ENST00000436791
ENST00000456345 ENSP00000415313
ENST00000476924
ENST00000489696
ENST00000460756
ENST00000470090
ENST00000490857
ENST00000476262
ENST00000477362
ENST00000530359 ENSP00000431725
ENST00000531278 ENSP00000432447
ENST00000525195 ENSP00000436920
ENST00000534203 ENSP00000435354
ENST00000524634 ENSP00000436289
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000266 mitochondrial fission
GO:0001836 release of cytochrome c from mitochondria
GO:0006626 protein targeting to mitochondrion
GO:0008053 mitochondrial fusion
GO:0010821 regulation of mitochondrion organization
GO:0016559 peroxisome fission
GO:0043653 mitochondrial fragmentation involved in apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0051260 protein homooligomerization
GO:0070584 mitochondrion morphogenesis
GO:0090141 positive regulation of mitochondrial fission
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0090314 positive regulation of protein targeting to membrane
GO:1900063 regulation of peroxisome organization
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005777 peroxisome
GO:0008021 synaptic vesicle
GO:0030054 cell junction
GO:0032592 integral component of mitochondrial membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026150
View Gene Order
ENSBTAG00000021319
Not yet available
Cross-References
SwissProt Q9GZY8
TrEMBL A0A024R491 C9J846 C9JAF1 C9JHF5 C9JI76 C9JU19 E9PK16 E9PKS0 E9PPR7 E9PPW6 E9PQX8 H7C433
UniProt Splice Variant
Entrez Gene 56947
UniGene Hs.471528 Hs.607992 Hs.708676 Hs.730366
RefSeq NM_001277061 NM_001277062 NM_001277063 NM_001277064 NM_001277065 NM_001277066 NM_001277067 NM_001277068 NM_020194 XM_006712638
HUGO HGNC:24858
OMIM 614785
CCDS CCDS2465 CCDS63139 CCDS63140 CCDS63141 CCDS63142 CCDS74662
HPRD
IMGT
EMBL AC097662 AF226049 AF246239 AF258660 AK026137 AL833032 BC000797 BC093024 CH471063
GenPept AAF86949 AAG44486 AAG44658 AAH00797 AAH93024 AAY24252 BAB15373 CAH56328 EAW70859 EAW70868
RNA Seq Atlas 56947

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca