InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SERPINE2

Summary

InnateDB Protein

IDBP-292979.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SERPINE2

Protein Name

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

Synonyms

GDN; GDNPF; PI-7; PI7; PN-1; PN1; PNI;

Species

Homo sapiens

Ensembl Protein

ENSP00000386969

InnateDB Gene

IDBG-82303 (SERPINE2)

Protein Structure

UniProt Annotation

Function

Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.

Subcellular Localization

Secreted, extracellular space.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0005539	glycosaminoglycan binding
GO:0008201	heparin binding

Biological Process

GO:0010757	negative regulation of plasminogen activation
GO:0010951	negative regulation of endopeptidase activity
GO:0010955	negative regulation of protein processing
GO:0030195	negative regulation of blood coagulation
GO:0030334	regulation of cell migration
GO:0045861	negative regulation of proteolysis
GO:0048711	positive regulation of astrocyte differentiation
GO:0090331	negative regulation of platelet aggregation

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005829	cytosol
GO:0031012	extracellular matrix
GO:0031091	platelet alpha granule
GO:0031232	extrinsic component of external side of plasma membrane
GO:0031594	neuromuscular junction