Version 5.4
Homo sapiens Protein: CETN1
Summary
InnateDB Protein IDBP-293.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CETN1
Protein Name centrin, EF-hand protein, 1
Synonyms CEN1; CETN;
Species Homo sapiens
Ensembl Protein ENSP00000319052
InnateDB Gene IDBG-291 (CETN1)
Protein Structure
UniProt Annotation
Function Plays a fundamental role in microtubule-organizing center structure and function.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Centrosome of interphase and mitotic cells.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 10 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008017 microtubule binding
GO:0008026 ATP-dependent helicase activity
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0032795 heterotrimeric G-protein binding
Biological Process
GO:0006200 ATP catabolic process
GO:0007067 mitotic nuclear division
GO:0034605 cellular response to heat
Cellular Component
GO:0000922 spindle pole
GO:0005813 centrosome
GO:0005814 centriole
GO:0032391 photoreceptor connecting cilium
Protein Structure and Domains
PDB ID
InterPro IPR002048 EF-hand domain
PFAM PF00036
PF13202
PF13405
PRINTS
PIRSF
SMART SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q12798
PhosphoSite PhosphoSite-Q12798
TrEMBL
UniProt Splice Variant
Entrez Gene 1068
UniGene Hs.122511
RefSeq NP_004057
HUGO HGNC:1866
OMIM 603187
CCDS CCDS11820
HPRD 04425
IMGT
EMBL AK312047 BC029515 CH471113 U03270
GenPept AAC27343 AAH29515 BAG34983 EAX01727

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca