Version 5.4
Homo sapiens Gene: CETN1
Summary
InnateDB Gene IDBG-291.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CETN1
Gene Name centrin, EF-hand protein, 1
Synonyms CEN1; CETN
Species Homo sapiens
Ensembl Gene ENSG00000177143
Encoded Proteins
IDBP-293
centrin, EF-hand protein, 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing. This encoded protein is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:580357-582114
Strand Forward strand
Band p11.32
Transcripts
ENST00000327228 ENSP00000319052
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 10 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008017 microtubule binding
GO:0008026 ATP-dependent helicase activity
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0032795 heterotrimeric G-protein binding
Biological Process
GO:0006200 ATP catabolic process
GO:0007067 mitotic nuclear division
GO:0034605 cellular response to heat
Cellular Component
GO:0000922 spindle pole
GO:0005813 centrosome
GO:0005814 centriole
GO:0032391 photoreceptor connecting cilium
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000050996
View Gene Order
ENSBTAG00000012320
Not yet available
Cross-References
SwissProt Q12798
TrEMBL
UniProt Splice Variant
Entrez Gene 1068
UniGene Hs.122511
RefSeq NM_004066
HUGO HGNC:1866
OMIM 603187
CCDS CCDS11820
HPRD
IMGT
EMBL AK312047 BC029515 CH471113 U03270
GenPept AAC27343 AAH29515 BAG34983 EAX01727
RNA Seq Atlas 1068

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca