InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATG9A

Summary

InnateDB Protein

IDBP-293015.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATG9A

Protein Name

ATG9 autophagy related 9 homolog A (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000386535

InnateDB Gene

IDBG-81394 (ATG9A)

Protein Structure

UniProt Annotation

Function

Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H. {ECO:0000269PubMed:16940348}.

Subcellular Localization

Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Under amino acid starvation or rapamycin treatment, redistributes from a juxtanuclear clustered pool to a dispersed peripheral cytosolic pool. The starvation- induced redistribution depends on ULK1, ATG13, as well as SH3GLB1.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	13 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015002	heme-copper terminal oxidase activity

Biological Process

GO:0000045	autophagic vacuole assembly
GO:0000422	mitochondrion degradation
GO:0015031	protein transport
GO:0034497	protein localization to pre-autophagosomal structure
GO:0034727	piecemeal microautophagy of nucleus
GO:0044805	late nucleophagy
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0000407	pre-autophagosomal structure
GO:0000421	autophagic vacuole membrane
GO:0005768	endosome
GO:0005776	autophagic vacuole
GO:0005789	endoplasmic reticulum membrane
GO:0005802	trans-Golgi network
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031410	cytoplasmic vesicle
GO:0031902	late endosome membrane