InnateDB Protein
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IDBP-293018.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ATG9A
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Protein Name
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ATG9 autophagy related 9 homolog A (S. cerevisiae)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000386710
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InnateDB Gene
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IDBG-81394 (ATG9A)
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Protein Structure
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Function |
Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H. {ECO:0000269PubMed:16940348}.
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Subcellular Localization |
Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Under amino acid starvation or rapamycin treatment, redistributes from a juxtanuclear clustered pool to a dispersed peripheral cytosolic pool. The starvation- induced redistribution depends on ULK1, ATG13, as well as SH3GLB1.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
15
[view]
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Protein-Protein |
13
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000298
Cytochrome c oxidase subunit III domain
IPR007241
Autophagy-related protein 9
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PFAM |
PF00510
PF04109
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q7Z3C6
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PhosphoSite |
PhosphoSite-Q7Z3C6
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TrEMBL |
C9JXG2
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UniProt Splice Variant |
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Entrez Gene |
79065
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UniGene |
Hs.603397
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RefSeq |
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HUGO |
HGNC:22408
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OMIM |
612204
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CCDS |
CCDS42820
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HPRD |
07979
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IMGT |
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EMBL |
AC068946
AK021732
AK025822
AK027448
AL833865
BC001098
BC021202
BC065534
BK004018
BX537984
BX538192
BX538198
CH471063
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GenPept |
AAH01098
AAH21202
AAH65534
BAB13882
BAB15246
BAB55119
CAD38723
CAD97944
CAD98061
CAD98064
DAA05199
EAW70706
EAW70707
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