Version 5.4
Homo sapiens Protein: A4GALT
Summary
InnateDB Protein IDBP-293020.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol A4GALT
Protein Name alpha 1,4-galactosyltransferase
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000384794
InnateDB Gene IDBG-10225 (A4GALT)
Protein Structure
UniProt Annotation
Function Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins.
Subcellular Localization Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Ubiquitous. Highly expressed in kidney, heart, spleen, liver, testis and placenta.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008378 galactosyltransferase activity
GO:0015643 toxic substance binding
GO:0050512 lactosylceramide 4-alpha-galactosyltransferase activity
Biological Process
GO:0001576 globoside biosynthetic process
GO:0006486 protein glycosylation
GO:0006688 glycosphingolipid biosynthetic process
GO:0007009 plasma membrane organization
Cellular Component
GO:0005795 Golgi stack
GO:0016020 membrane
GO:0030173 integral component of Golgi membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR007577 Glycosyltransferase, DXD sugar-binding motif
IPR007652 Alpha 1,4-glycosyltransferase domain
PFAM PF04488
PF04572
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NPC4
PhosphoSite PhosphoSite-Q9NPC4
TrEMBL S6CQT5
UniProt Splice Variant
Entrez Gene 53947
UniGene Hs.105956
RefSeq XP_006724330
HUGO HGNC:18149
OMIM 607922
CCDS CCDS14041
HPRD 06390
IMGT
EMBL AB037883 AB041418 AF513326 AF513327 AJ245581 AK312927 AY941797 BC017068 CH471138 HE818931 HE818932 KC202808 Z82176
GenPept AAH17068 AAP47167 AAP47168 AAX20109 AGF29465 BAA94503 BAA95915 BAG35771 CAB93532 CAI18757 CCH64301 CCH64302 EAW73274

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca