InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HERC3

Summary

InnateDB Protein

IDBP-293044.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HERC3

Protein Name

hect domain and RLD 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000385684

InnateDB Gene

IDBG-29858 (HERC3)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000250}.

Subcellular Localization

Cytoplasm. Cytoplasmic vesicle. Note=Also found in vesicular-like structures.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0016874	ligase activity

Biological Process

GO:0016567	protein ubiquitination
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Cellular Component

GO:0005634	nucleus
GO:0016023	cytoplasmic membrane-bounded vesicle

Protein Structure and Domains

PDB ID

InterPro

IPR000408 Regulator of chromosome condensation, RCC1
IPR000569 HECT
IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II

PFAM

PF00415
PF00632

PRINTS

PR00633

PIRSF

SMART

SM00119

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt