InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FCGR2B

Summary

InnateDB Protein

IDBP-293072.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FCGR2B

Protein Name

Fc fragment of IgG, low affinity IIb, receptor (CD32)

Synonyms

CD32; CD32B; FCG2; FCGR2; IGFR2;

Species

Homo sapiens

Ensembl Protein

ENSP00000386038

InnateDB Gene

IDBG-104308 (FCGR2B)

Protein Structure

UniProt Annotation

Function

Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B- cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.

Disease Associations

Note=A chromosomal aberration involving FCGR2B is found in a follicular lymphoma. Translocation t(1;22)(q22;q11). The translocation leads to the hyperexpression of the receptor. This may play a role in the tumor progression.Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269PubMed:12115230, ECO:0000269PubMed:20385827}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Is the most broadly distributed Fc-gamma- receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019864	IgG binding

Biological Process

GO:0006955	immune response
GO:0007165	signal transduction
GO:0016032	viral process
GO:0050776	regulation of immune response

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain

PFAM

PRINTS

PIRSF

SMART

SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P31994

PhosphoSite

PhosphoSite-P31994

TrEMBL

Q8NIA0

UniProt Splice Variant

Entrez Gene

2213

UniGene

Hs.666187

RefSeq

HUGO

HGNC:3618

OMIM

604590

CCDS

HPRD

06849

IMGT

EMBL

AB050934 AB051387 AB060143 AB060147 AB060149 AB060150 AB062416 AF433951 AL359541 BC031992 BC146678 CR407635 M31933 M31934 M31935 U87560 U87561 U87562 U87563 U87564 U87565 U87566 U87567 U87568 U87569 U87570 U87571 U87572 U87573 U87574 U87575 U87576 U87577 X17653 X52473

GenPept

AAA35841 AAA35842 AAA35843 AAD00627 AAD00628 AAD00629 AAD00630 AAD00631 AAD00632 AAD00633 AAD00634 AAD00635 AAD00636 AAD00637 AAD00638 AAD00639 AAD00640 AAD00641 AAD00642 AAD00643 AAD00644 AAH31992 AAI46679 AAN14522 BAB92093 BAB92094 BAB92095 BAC54013 BAC54017 BAC54019 BAC54020 CAA35644 CAA35645 CAA36713 CAG28563