InnateDB Protein
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IDBP-293330.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TFPI
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Protein Name
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tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
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Synonyms
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EPI; LACI; TFI; TFPI1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000386344
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InnateDB Gene
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IDBG-77150 (TFPI)
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Protein Structure
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Function |
Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.
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Subcellular Localization |
Isoform Alpha: Secreted.Isoform Beta: Microsome membrane {ECO:0000269PubMed:22144186}; Lipid-anchor, GPI-anchor {ECO:0000269PubMed:22144186}.
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Disease Associations |
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Tissue Specificity |
Mostly in endothelial cells.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
14
[view]
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Protein-Protein |
13
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0004866
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endopeptidase inhibitor activity
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GO:0004867
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serine-type endopeptidase inhibitor activity
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GO:0030414
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peptidase inhibitor activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002223
Proteinase inhibitor I2, Kunitz metazoa
IPR008296
Proteinase inhibitor I2, tissue factor pathway inhibitor
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PFAM |
PF00014
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PRINTS |
PR00759
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PIRSF |
PIRSF001620
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SMART |
SM00131
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TIGRFAMs |
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Modification |
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SwissProt |
P10646
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PhosphoSite |
PhosphoSite-P10646
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TrEMBL |
C9JT76
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UniProt Splice Variant |
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Entrez Gene |
7035
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UniGene |
Hs.619450
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RefSeq |
XP_005246877
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HUGO |
HGNC:11760
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OMIM |
152310
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CCDS |
CCDS33349
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HPRD |
01064
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IMGT |
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EMBL |
AC007319
AC098485
AF021834
AY263365
BC015514
CH471058
J03225
M58644
M58645
M58646
M58647
M58648
M58649
M58650
M59493
M59494
M59495
M59496
M59497
M59498
M59499
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GenPept |
AAA52022
AAA59480
AAA59526
AAD01700
AAH15514
AAO89075
AAY14807
EAX10921
EAX10922
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