InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NRXN1

Summary

InnateDB Protein

IDBP-293425.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NRXN1

Protein Name

neurexin 1

Synonyms

Hs.22998; PTHSL2; SCZD17;

Species

Homo sapiens

Ensembl Protein

ENSP00000385142

InnateDB Gene

IDBG-51547 (NRXN1)

Protein Structure

UniProt Annotation

Function

Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)- triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their calcium-dependent interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell junction, synapse {ECO:0000305}. Note=Localized on the pre-synaptic membrane. {ECO:0000250}.

Disease Associations

Tissue Specificity

Brain. {ECO:0000269PubMed:9628581}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005246	calcium channel regulator activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0033130	acetylcholine receptor binding
GO:0048306	calcium-dependent protein binding
GO:0050839	cell adhesion molecule binding
GO:0097109	neuroligin family protein binding

Biological Process

GO:0007157	heterophilic cell-cell adhesion
GO:0007158	neuron cell-cell adhesion
GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0007411	axon guidance
GO:0007416	synapse assembly
GO:0007612	learning
GO:0016339	calcium-dependent cell-cell adhesion
GO:0021707	cerebellar granule cell differentiation
GO:0030198	extracellular matrix organization
GO:0030534	adult behavior
GO:0035176	social behavior
GO:0035418	protein localization to synapse
GO:0042297	vocal learning
GO:0042551	neuron maturation
GO:0045184	establishment of protein localization
GO:0050885	neuromuscular process controlling balance
GO:0051490	negative regulation of filopodium assembly
GO:0051965	positive regulation of synapse assembly
GO:0051968	positive regulation of synaptic transmission, glutamatergic
GO:0071625	vocalization behavior
GO:0090004	positive regulation of establishment of protein localization to plasma membrane
GO:0090129	positive regulation of synapse maturation
GO:0097091	synaptic vesicle clustering
GO:0097104	postsynaptic membrane assembly
GO:0097105	presynaptic membrane assembly
GO:0097112	gamma-aminobutyric acid receptor clustering
GO:0097114	N-methyl-D-aspartate receptor clustering
GO:0097116	gephyrin clustering
GO:0097117	guanylate kinase-associated protein clustering
GO:0097118	neuroligin clustering
GO:0097119	postsynaptic density protein 95 clustering
GO:0097120	receptor localization to synapse
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
GO:2000463	positive regulation of excitatory postsynaptic membrane potential

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0030054	cell junction
GO:0042734	presynaptic membrane
GO:0044295	axonal growth cone

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001791 Laminin G domain
IPR003585 Neurexin/syndecan/glycophorin C
IPR008985 Concanavalin A-like lectin/glucanases superfamily

PFAM

PF00008
PF00054
PF02210

PRINTS

PIRSF

SMART

SM00181
SM00210
SM00282
SM00294

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9ULB1