Version 5.4
Homo sapiens Gene: NRXN1
Summary
InnateDB Gene IDBG-51547.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NRXN1
Gene Name neurexin 1
Synonyms Hs.22998; PTHSL2; SCZD17
Species Homo sapiens
Ensembl Gene ENSG00000179915
Encoded Proteins
IDBP-51551
neurexin 1
IDBP-51609
neurexin 1
IDBP-293438
neurexin 1
IDBP-591688
neurexin 1
IDBP-293425
neurexin 1
IDBP-293423
neurexin 1
IDBP-293429
neurexin 1
IDBP-293428
neurexin 1
IDBP-293424
neurexin 1
IDBP-293420
neurexin 1
IDBP-375501
neurexin 1
IDBP-813370
neurexin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Neurexins function in the vertebrate nervous system as cell adhesion molecules and receptors. Two neurexin genes are among the largest known in human (NRXN1 and NRXN3). By using alternate promoters, splice sites and exons, predictions of hundreds or even thousands of distinct mRNAs have been made. Most transcripts use the upstream promoter and encode alpha-neurexin isoforms; fewer transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. Alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and they interact with neurexophilins. Beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. The RefSeq Project has decided to create only a few representative transcript variants of the multitude that are possible. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:49918505-51032536
Strand Reverse strand
Band p16.3
Transcripts
ENST00000331040
ENST00000342183 ENSP00000341184
ENST00000378262 ENSP00000367510
ENST00000402717 ENSP00000385434
ENST00000405472 ENSP00000434015
ENST00000404971 ENSP00000385142
ENST00000406316 ENSP00000384311
ENST00000401669 ENSP00000385017
ENST00000401710 ENSP00000385580
ENST00000406859 ENSP00000385681
ENST00000405581 ENSP00000385310
ENST00000412315 ENSP00000396738
ENST00000484192
ENST00000474354
ENST00000462791
ENST00000495871
ENST00000496792
ENST00000611589 ENSP00000483634
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005102 receptor binding
GO:0005246 calcium channel regulator activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0033130 acetylcholine receptor binding
GO:0046872 metal ion binding
GO:0048306 calcium-dependent protein binding
GO:0050839 cell adhesion molecule binding
GO:0097109 neuroligin family protein binding
Biological Process
GO:0001525 angiogenesis
GO:0007157 heterophilic cell-cell adhesion
GO:0007158 neuron cell-cell adhesion
GO:0007268 synaptic transmission
GO:0007269 neurotransmitter secretion
GO:0007411 axon guidance
GO:0007416 synapse assembly
GO:0007612 learning
GO:0016339 calcium-dependent cell-cell adhesion
GO:0021707 cerebellar granule cell differentiation
GO:0023041 neuronal signal transduction
GO:0030198 extracellular matrix organization
GO:0030534 adult behavior
GO:0035176 social behavior
GO:0035418 protein localization to synapse
GO:0042297 vocal learning
GO:0042551 neuron maturation
GO:0045184 establishment of protein localization
GO:0050885 neuromuscular process controlling balance
GO:0051490 negative regulation of filopodium assembly
GO:0051965 positive regulation of synapse assembly
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0071625 vocalization behavior
GO:0090004 positive regulation of establishment of protein localization to plasma membrane
GO:0090129 positive regulation of synapse maturation
GO:0097091 synaptic vesicle clustering
GO:0097104 postsynaptic membrane assembly
GO:0097105 presynaptic membrane assembly
GO:0097112 gamma-aminobutyric acid receptor clustering
GO:0097114 N-methyl-D-aspartate receptor clustering
GO:0097116 gephyrin clustering
GO:0097117 guanylate kinase-associated protein clustering
GO:0097118 neuroligin clustering
GO:0097119 postsynaptic density protein 95 clustering
GO:0097120 receptor localization to synapse
GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
GO:2000463 positive regulation of excitatory postsynaptic membrane potential
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030139 endocytic vesicle
GO:0042734 presynaptic membrane
GO:0044295 axonal growth cone
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000024109
View Gene Order
Pathways
NETPATH
REACTOME
REACT_118779
Extracellular matrix organization pathway
REACT_163874
Non-integrin membrane-ECM interactions pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
Cross-References
SwissProt Q9ULB1
TrEMBL A7E294 Q08AH0
UniProt Splice Variant
Entrez Gene 9378
UniGene Hs.597143 Hs.620027 Hs.637685 Hs.733743
RefSeq XM_005264643 NM_001135659 NM_004801 NM_138735 XM_005264642 XM_006712133 XM_006712137 XM_006712138 XM_006712140 XM_006712141 XM_006712144
HUGO HGNC:8008
OMIM 600565
CCDS CCDS1845 CCDS46282 CCDS54360
HPRD 11858
IMGT
EMBL AB011150 AB035356 AC007462 AC007682 AC009234 AC068715 AC068725 AC069550 AC078994 BC125180 BC150247 EF539882
GenPept AAF03536 AAG38120 AAG59602 AAG59642 AAI25181 AAI50248 AAK06387 AAY14894 AAY14944 ABS86974 BAA25504 BAA87821
RNA Seq Atlas 9378

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca