Version 5.4
Homo sapiens Protein: CBX6
Summary
InnateDB Protein IDBP-293501.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CBX6
Protein Name chromobox homolog 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000384490
InnateDB Gene IDBG-7818 (CBX6)
Protein Structure
UniProt Annotation
Function Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269PubMed:21282530}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 68 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 68 [view]
Protein-Protein 68 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003727 single-stranded RNA binding
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0016568 chromatin modification
Cellular Component
GO:0000792 heterochromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0031519 PcG protein complex
Protein Structure and Domains
PDB ID
InterPro IPR000953 Chromo domain/shadow
IPR016197 Chromo domain-like
IPR017984 Chromo domain subgroup
IPR023780 Chromo domain
PFAM PF00385
PRINTS PR00504
PIRSF
SMART SM00298
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95503
PhosphoSite PhosphoSite-O95503
TrEMBL
UniProt Splice Variant
Entrez Gene 23466
UniGene Hs.682605
RefSeq NP_055107
HUGO HGNC:1556
OMIM
CCDS CCDS13980
HPRD 13005
IMGT
EMBL AK293035 AL008583 BC012111 BC064900 CH471095
GenPept AAH12111 AAH64900 BAF85724 CAA15431 EAW60276

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca