InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RRP8

Summary

InnateDB Protein

IDBP-29351.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RRP8

Protein Name

ribosomal RNA processing 8, methyltransferase, homolog (yeast)

Synonyms

KIAA0409; NML;

Species

Homo sapiens

Ensembl Protein

ENSP00000254605

InnateDB Gene

IDBG-29349 (RRP8)

Protein Structure

UniProt Annotation

Function

Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys- 9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. {ECO:0000269PubMed:18485871}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000269PubMed:11790298, ECO:0000269PubMed:12429849, ECO:0000269PubMed:18485871}. Note=Localizes at rDNA locus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity
GO:0035064	methylated histone binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000183	chromatin silencing at rDNA
GO:0006351	transcription, DNA-templated
GO:0006364	rRNA processing
GO:0008152	metabolic process
GO:0016568	chromatin modification
GO:0032259	methylation
GO:0042149	cellular response to glucose starvation
GO:0046015	regulation of transcription by glucose
GO:0071158	positive regulation of cell cycle arrest
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator