Version 5.4
Homo sapiens Gene: RRP8
Summary
InnateDB Gene IDBG-29349.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RRP8
Gene Name ribosomal RNA processing 8, methyltransferase, homolog (yeast)
Synonyms KIAA0409; NML
Species Homo sapiens
Ensembl Gene ENSG00000132275
Encoded Proteins
IDBP-29351
ribosomal RNA processing 8, methyltransferase, homolog (yeast)
IDBP-593609
ribosomal RNA processing 8, methyltransferase, homolog (yeast)
IDBP-602530
ribosomal RNA processing 8, methyltransferase, homolog (yeast)
IDBP-594719
ribosomal RNA processing 8, methyltransferase, homolog (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 11:6595075-6603620
Strand Reverse strand
Band p15.4
Transcripts
ENST00000254605 ENSP00000254605
ENST00000534343 ENSP00000436960
ENST00000526352
ENST00000533907 ENSP00000436246
ENST00000530762 ENSP00000435873
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0035064 methylated histone binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000183 chromatin silencing at rDNA
GO:0006351 transcription, DNA-templated
GO:0006364 rRNA processing
GO:0008152 metabolic process
GO:0016568 chromatin modification
GO:0032259 methylation
GO:0042149 cellular response to glucose starvation
GO:0046015 regulation of transcription by glucose
GO:0071158 positive regulation of cell cycle arrest
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
Cellular Component
GO:0005634 nucleus
GO:0005677 chromatin silencing complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0033553 rDNA heterochromatin
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030888
View Gene Order
ENSBTAG00000000697
Not yet available
Pathways
NETPATH
REACTOME
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_200827
SIRT1 negatively regulates rRNA Expression pathway
REACT_71
Gene Expression pathway
REACT_200834
Negative epigenetic regulation of rRNA expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9PPP6
UniProt Splice Variant
Entrez Gene 23378
UniGene Hs.601715 Hs.652255
RefSeq NM_015324
HUGO HGNC:29030
OMIM 615818
CCDS CCDS31411
HPRD 13800
IMGT
EMBL AC009796 AC091564
GenPept
RNA Seq Atlas 23378

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca