InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DDX17

Summary

InnateDB Protein

IDBP-293576.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDX17

Protein Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 17

Synonyms

P72; RH70;

Species

Homo sapiens

Ensembl Protein

ENSP00000385536

InnateDB Gene

IDBG-7557 (DDX17)

Protein Structure

UniProt Annotation

Function

RNA-dependent ATPase activity. Involved in transcriptional regulation. Transcriptional coactivator for estrogen receptor ESR1. Increases ESR1 AF-1 domain-mediated transactivation. Synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and probably involved in skeletal muscle differentiation. Required for zinc-finger antiviral protein ZC3HAV1-mediated mRNA degradation. {ECO:0000269PubMed:11250900, ECO:0000269PubMed:15298701, ECO:0000269PubMed:17011493, ECO:0000269PubMed:17226766, ECO:0000269PubMed:18334637, ECO:0000269PubMed:19718048}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:22002106}. Nucleus, nucleolus {ECO:0000269PubMed:22002106}.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 166 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	166 [view]
Protein-Protein	151 [view]
Protein-DNA	2 [view]
Protein-RNA	2 [view]
DNA-DNA	11 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003713	transcription coactivator activity
GO:0003723	RNA binding
GO:0003724	RNA helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0008186	RNA-dependent ATPase activity
GO:0030331	estrogen receptor binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006351	transcription, DNA-templated
GO:0006396	RNA processing
GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:2001014	regulation of skeletal muscle cell differentiation

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR011545 DEAD/DEAH box helicase domain
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR014014 RNA helicase, DEAD-box type, Q motif
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF00270

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q92841