Version 5.4
Homo sapiens Protein: PTPRN2
Summary
InnateDB Protein IDBP-293621.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPRN2
Protein Name protein tyrosine phosphatase, receptor type, N polypeptide 2
Synonyms IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2;
Species Homo sapiens
Ensembl Protein ENSP00000385464
InnateDB Gene IDBG-50943 (PTPRN2)
Protein Structure
UniProt Annotation
Function Implicated in development of nervous system and pancreatic endocrine cells. {ECO:0000269PubMed:8798755, ECO:0000269PubMed:8878534}.
Subcellular Localization Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Highest levels in brain and pancreas. Lower levels in trachea, prostate, stomach and spinal chord.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 5 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0030658 transport vesicle membrane
GO:0043235 receptor complex
Protein Structure and Domains
PDB ID
InterPro IPR021613 Protein-tyrosine phosphatase receptor IA-2 ectodomain
PFAM PF11548
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q92932
PhosphoSite PhosphoSite-Q92932
TrEMBL
UniProt Splice Variant
Entrez Gene 5799
UniGene Hs.642479
RefSeq
HUGO HGNC:9677
OMIM 601698
CCDS
HPRD 03413
IMGT
EMBL AB002385 AC005481 AC006003 AC006372 AC011899 AC019043 AC078942 AC093662 AC093856 AC125243 AF007555 BC034040 U66702 U81561 Y08569
GenPept AAB63600 AAB68603 AAC50742 AAH34040 BAA20841 CAA69880

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca