InnateDB Protein
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IDBP-293634.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DYNC1I2
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Protein Name
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dynein, cytoplasmic 1, intermediate chain 2
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Synonyms
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DNCI2; IC2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000386591
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InnateDB Gene
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IDBG-74949 (DYNC1I2)
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Protein Structure
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Function |
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150- glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes.
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Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
38
[view]
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Protein-Protein |
38
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001680
WD40 repeat
IPR017986
WD40-repeat-containing domain
IPR025956
Cytoplasmic dynein 1 intermediate chain 1/2
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PFAM |
PF00400
PF11540
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PRINTS |
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PIRSF |
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SMART |
SM00320
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TIGRFAMs |
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Modification |
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SwissProt |
Q13409
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PhosphoSite |
PhosphoSite-Q13409
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TrEMBL |
Q53SA6
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UniProt Splice Variant |
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Entrez Gene |
1781
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UniGene |
Hs.743362
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RefSeq |
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HUGO |
HGNC:2964
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OMIM |
603331
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CCDS |
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HPRD |
04512
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IMGT |
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EMBL |
AC064826
AC068039
AF134477
AF250307
AK055491
AK316119
AL137519
AY037160
BC015038
BC091498
BC109375
BT007130
BX537412
CH471058
U39575
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GenPept |
AAA89166
AAH15038
AAH91498
AAI09376
AAK37426
AAK67638
AAP35794
AAP97254
AAX93177
AAY24133
BAB70932
BAH14490
CAB70785
CAD97654
EAX11202
EAX11204
EAX11206
EAX11207
EAX11208
EAX11209
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