Version 5.4
Homo sapiens Gene: DYNC1I2
Summary
InnateDB Gene IDBG-74949.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DYNC1I2
Gene Name dynein, cytoplasmic 1, intermediate chain 2
Synonyms DNCI2; IC2
Species Homo sapiens
Ensembl Gene ENSG00000077380
Encoded Proteins
IDBP-74951
dynein, cytoplasmic 1, intermediate chain 2
IDBP-236055
dynein, cytoplasmic 1, intermediate chain 2
IDBP-293640
dynein, cytoplasmic 1, intermediate chain 2
IDBP-293636
dynein, cytoplasmic 1, intermediate chain 2
IDBP-293634
dynein, cytoplasmic 1, intermediate chain 2
IDBP-293631
dynein, cytoplasmic 1, intermediate chain 2
IDBP-293632
dynein, cytoplasmic 1, intermediate chain 2
IDBP-387514
dynein, cytoplasmic 1, intermediate chain 2
IDBP-387518
dynein, cytoplasmic 1, intermediate chain 2
IDBP-387519
dynein, cytoplasmic 1, intermediate chain 2
IDBP-387521
dynein, cytoplasmic 1, intermediate chain 2
IDBP-387522
dynein, cytoplasmic 1, intermediate chain 2
IDBP-387525
dynein, cytoplasmic 1, intermediate chain 2
IDBP-387526
dynein, cytoplasmic 1, intermediate chain 2
IDBP-387527
dynein, cytoplasmic 1, intermediate chain 2
IDBP-387529
dynein, cytoplasmic 1, intermediate chain 2
IDBP-387530
dynein, cytoplasmic 1, intermediate chain 2
IDBP-387531
dynein, cytoplasmic 1, intermediate chain 2
IDBP-387532
dynein, cytoplasmic 1, intermediate chain 2
IDBP-477579
dynein, cytoplasmic 1, intermediate chain 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the dynein intermediate chain family. The encoded protein is a non-catalytic component of the cytoplasmic dynein 1 complex, which acts as a retrograde microtubule motor to transport organelles and vesicles. A pseudogene of this gene is located on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:171687409-171748420
Strand Forward strand
Band q31.1
Transcripts
ENST00000340296 ENSP00000339430
ENST00000397119 ENSP00000380308
ENST00000410079 ENSP00000386522
ENST00000409197 ENSP00000386397
ENST00000409317 ENSP00000386591
ENST00000409773 ENSP00000386415
ENST00000409453 ENSP00000386886
ENST00000452242 ENSP00000398765
ENST00000438879 ENSP00000392741
ENST00000456808 ENSP00000388699
ENST00000411953 ENSP00000405454
ENST00000445378 ENSP00000415410
ENST00000435234 ENSP00000410807
ENST00000443458 ENSP00000401005
ENST00000412370 ENSP00000406104
ENST00000425485 ENSP00000394492
ENST00000423910 ENSP00000397654
ENST00000430778 ENSP00000409951
ENST00000422646 ENSP00000403089
ENST00000471482
ENST00000508530 ENSP00000423339
ENST00000482454
ENST00000476551
ENST00000470286
ENST00000479806
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
Experimentally validated
Total 38 [view]
Protein-Protein 38 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003777 microtubule motor activity
GO:0005515 protein binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0006810 transport
GO:0007018 microtubule-based movement
GO:0008152 metabolic process
GO:0016032 viral process
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005868 cytoplasmic dynein complex
GO:0005874 microtubule
GO:0031982 vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027012
View Gene Order
ENSBTAG00000002646
Not yet available
Pathways
NETPATH
REACTOME
REACT_160315
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_15364
Loss of Nlp from mitotic centrosomes pathway
REACT_15451
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
REACT_15296
Recruitment of mitotic centrosome proteins and complexes pathway
REACT_121399
MHC class II antigen presentation pathway
REACT_115566
Cell Cycle pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_15479
Centrosome maturation pathway
REACT_2203
G2/M Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_21391
Mitotic G2-G2/M phases pathway
KEGG
hsa04962
Vasopressin-regulated water reabsorption pathway
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt Q13409
TrEMBL E7EQL5 E7EQU2 Q53SA6
UniProt Splice Variant
Entrez Gene 1781
UniGene Hs.743362
RefSeq NM_001271789 NM_001271785 NM_001271786 NM_001271787 NM_001271788 NM_001271790 NM_001378 XM_005246366 XM_005246367 XM_005246369 XM_006712347
HUGO HGNC:2964
OMIM 603331
CCDS CCDS63056 CCDS46450 CCDS63054 CCDS63057
HPRD 04512
IMGT
EMBL AC064826 AC068039 AF134477 AF250307 AK055491 AK316119 AL137519 AY037160 BC015038 BC091498 BC109375 BT007130 BX537412 CH471058 U39575
GenPept AAA89166 AAH15038 AAH91498 AAI09376 AAK37426 AAK67638 AAP35794 AAP97254 AAX93177 AAY24133 BAB70932 BAH14490 CAB70785 CAD97654 EAX11202 EAX11204 EAX11206 EAX11207 EAX11208 EAX11209
RNA Seq Atlas 1781

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca