InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NCOR2

Summary

InnateDB Protein

IDBP-293635.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NCOR2

Protein Name

nuclear receptor corepressor 2

Synonyms

CTG26; N-CoR2; SMAP270; SMRT; SMRTE; SMRTE-tau; TNRC14; TRAC; TRAC-1; TRAC1;

Species

Homo sapiens

Ensembl Protein

ENSP00000384018

InnateDB Gene

IDBG-63911 (NCOR2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 188 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	188 [view]
Protein-Protein	173 [view]
Protein-DNA	10 [view]
Protein-RNA	0
DNA-DNA	4 [view]
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001012	RNA polymerase II regulatory region DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003714	transcription corepressor activity
GO:0005112	Notch binding
GO:0005515	protein binding
GO:0016922	ligand-dependent nuclear receptor binding
GO:0032403	protein complex binding
GO:0035259	glucocorticoid receptor binding
GO:0042826	histone deacetylase binding
GO:0042974	retinoic acid receptor binding
GO:0043565	sequence-specific DNA binding
GO:0046965	retinoid X receptor binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0003007	heart morphogenesis
GO:0006351	transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007219	Notch signaling pathway
GO:0007595	lactation
GO:0010243	response to organonitrogen compound
GO:0010467	gene expression
GO:0021537	telencephalon development
GO:0021846	cell proliferation in forebrain
GO:0030900	forebrain development
GO:0032355	response to estradiol
GO:0042593	glucose homeostasis
GO:0042698	ovulation cycle
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045599	negative regulation of fat cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0050872	white fat cell differentiation
GO:0060206	estrous cycle phase
GO:0060509	Type I pneumocyte differentiation
GO:0072365	regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0000118	histone deacetylase complex
GO:0000785	chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0016020	membrane
GO:0016363	nuclear matrix
GO:0016604	nuclear body
GO:0017053	transcriptional repressor complex