InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SETD8

Summary

InnateDB Protein

IDBP-293660.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SETD8

Protein Name

SET domain containing (lysine methyltransferase) 8

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000384629

InnateDB Gene

IDBG-63410 (SETD8)

Protein Structure

UniProt Annotation

Function

Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration. {ECO:0000269PubMed:12086618, ECO:0000269PubMed:12121615, ECO:0000269PubMed:15200950, ECO:0000269PubMed:15933069, ECO:0000269PubMed:15933070, ECO:0000269PubMed:16517599, ECO:0000269PubMed:17707234, ECO:0000269PubMed:23478445}.

Subcellular Localization

Nucleus. Chromosome. Note=Specifically localizes to mitotic chromosomes. Colocalized with SIRT2 at mitotic foci. Associates with chromosomes during mitosis; association is increased in a H(2)O(2)-induced oxidative stress- dependent manner. Associates with silent chromatin on euchromatic arms. Not associated with constitutive heterochromatin.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	36 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0016279	protein-lysine N-methyltransferase activity
GO:0018024	histone-lysine N-methyltransferase activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000278	mitotic cell cycle
GO:0006351	transcription, DNA-templated
GO:0007067	mitotic nuclear division
GO:0018026	peptidyl-lysine monomethylation
GO:0034968	histone lysine methylation
GO:0043516	regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045892	negative regulation of transcription, DNA-templated