Version 5.4
Homo sapiens Gene: SETD8
Summary
InnateDB Gene IDBG-63410.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SETD8
Gene Name SET domain containing (lysine methyltransferase) 8
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000183955
Encoded Proteins
IDBP-63412
SET domain containing (lysine methyltransferase) 8
IDBP-293660
SET domain containing (lysine methyltransferase) 8
IDBP-384846
SET domain containing (lysine methyltransferase) 8
IDBP-384847
SET domain containing (lysine methyltransferase) 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 12:123383773-123409358
Strand Forward strand
Band q24.31
Transcripts
ENST00000330479 ENSP00000332995
ENST00000402868 ENSP00000384629
ENST00000437519 ENSP00000406830
ENST00000437502 ENSP00000413811
ENST00000478781
ENST00000461103
ENST00000462311
ENST00000485469
ENST00000537270
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 36 [view]
Protein-Protein 36 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002039 p53 binding
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0016279 protein-lysine N-methyltransferase activity
GO:0018024 histone-lysine N-methyltransferase activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000278 mitotic cell cycle
GO:0006351 transcription, DNA-templated
GO:0007067 mitotic nuclear division
GO:0018026 peptidyl-lysine monomethylation
GO:0034968 histone lysine methylation
GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000049327
View Gene Order
ENSBTAG00000000139
Not yet available
Pathways
NETPATH
REACTOME
REACT_172744
Condensation of Prophase Chromosomes pathway
REACT_115566
Cell Cycle pathway
REACT_910
M Phase pathway
REACT_765
Mitotic Prophase pathway
REACT_152
Cell Cycle, Mitotic pathway
KEGG
hsa00310
Lysine degradation pathway
INOH
PID NCI
p53regulationpathway
p53 pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.443735 Hs.674365
RefSeq NM_020382 XM_006719394
HUGO
OMIM
CCDS CCDS9247
HPRD 06254
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca