Version 5.4
Homo sapiens Protein: ECE2
Summary
InnateDB Protein IDBP-293695.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ECE2
Protein Name endothelin converting enzyme 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000385846
InnateDB Gene IDBG-67656 (ECE2)
Protein Structure
UniProt Annotation
Function Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta- amyloid peptide accumulation in brain. May also have methyltransferase activity. {ECO:0000269PubMed:12560336}.
Subcellular Localization Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Cytoplasmic granule membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in brain. Strongly down-regulated in inferior parietal lobe from Alzheimer disease patients (at protein level). {ECO:0000269PubMed:17188679}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0008168 methyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0007267 cell-cell signaling
GO:0007420 brain development
GO:0007507 heart development
GO:0010002 cardioblast differentiation
GO:0016486 peptide hormone processing
GO:0032259 methylation
Cellular Component
GO:0000139 Golgi membrane
GO:0016021 integral component of membrane
GO:0030659 cytoplasmic vesicle membrane
Protein Structure and Domains
PDB ID
InterPro IPR008753 Peptidase M13, N-terminal domain
IPR018497 Peptidase M13, C-terminal domain
PFAM PF05649
PF01431
PRINTS PR00786
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O60344
PhosphoSite PhosphoSite-O60344
TrEMBL
UniProt Splice Variant
Entrez Gene 9718
UniGene Hs.585003
RefSeq NP_001093591
HUGO HGNC:13275
OMIM 610145
CCDS CCDS46969
HPRD 09931
IMGT
EMBL AB011176 AC061705 AC078797 AF192531 AF428263 AF428264 AF521189 AY359003 BC005835 BC012449 BC069005 BC142950 CH471052
GenPept AAG28399 AAH05835 AAH12449 AAH69005 AAI42951 AAL30386 AAL30387 AAM77664 AAQ89362 BAA25530 EAW78277

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca