InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PICK1

Summary

InnateDB Protein

IDBP-293697.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PICK1

Protein Name

protein interacting with PRKCA 1

Synonyms

PICK; PRKCABP;

Species

Homo sapiens

Ensembl Protein

ENSP00000385205

InnateDB Gene

IDBG-7244 (PICK1)

Protein Structure

UniProt Annotation

Function

Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function. {ECO:0000269PubMed:20403402}.

Subcellular Localization

Cytoplasm, perinuclear region. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Also membrane-associated, present at excitatory synapses. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	53 [view]
Protein-Protein	52 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005080	protein kinase C binding
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0016887	ATPase activity
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding
GO:0046872	metal ion binding
GO:0051015	actin filament binding
GO:0071933	Arp2/3 complex binding

Biological Process

GO:0002092	positive regulation of receptor internalization
GO:0006200	ATP catabolic process
GO:0006468	protein phosphorylation
GO:0006605	protein targeting
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007268	synaptic transmission
GO:0015844	monoamine transport
GO:0021782	glial cell development
GO:0034316	negative regulation of Arp2/3 complex-mediated actin nucleation
GO:0036294	cellular response to decreased oxygen levels
GO:0042149	cellular response to glucose starvation
GO:0043045	DNA methylation involved in embryo development
GO:0043046	DNA methylation involved in gamete generation
GO:0043113	receptor clustering
GO:0045161	neuronal ion channel clustering
GO:0060292	long term synaptic depression
GO:0097061	dendritic spine organization
GO:0097062	dendritic spine maintenance

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0014069	postsynaptic density
GO:0030054	cell junction
GO:0030666	endocytic vesicle membrane
GO:0042734	presynaptic membrane
GO:0043005	neuron projection
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0048471	perinuclear region of cytoplasm
GO:0097481	neuronal postsynaptic density