Version 5.4
Homo sapiens Gene: PICK1
Summary
InnateDB Gene IDBG-7244.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PICK1
Gene Name protein interacting with PRKCA 1
Synonyms PICK; PRKCABP
Species Homo sapiens
Ensembl Gene ENSG00000100151
Encoded Proteins
IDBP-7246
protein interacting with PRKCA 1
IDBP-293697
protein interacting with PRKCA 1
IDBP-376226
protein interacting with PRKCA 1
IDBP-376229
protein interacting with PRKCA 1
IDBP-376235
protein interacting with PRKCA 1
IDBP-376236
protein interacting with PRKCA 1
IDBP-376240
protein interacting with PRKCA 1
IDBP-376248
protein interacting with PRKCA 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:38056311-38075701
Strand Forward strand
Band q13.1
Transcripts
ENST00000356976 ENSP00000349465
ENST00000404072 ENSP00000385205
ENST00000445628 ENSP00000416487
ENST00000424694 ENSP00000398141
ENST00000432756 ENSP00000387861
ENST00000437453 ENSP00000410793
ENST00000426258 ENSP00000413962
ENST00000435166 ENSP00000397588
ENST00000484021
ENST00000476157
ENST00000468288
ENST00000469819
ENST00000466374
ENST00000472724
ENST00000494434
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 53 [view]
Protein-Protein 52 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005080 protein kinase C binding
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0016887 ATPase activity
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0046872 metal ion binding
GO:0051015 actin filament binding
GO:0071933 Arp2/3 complex binding
Biological Process
GO:0002092 positive regulation of receptor internalization
GO:0006200 ATP catabolic process
GO:0006468 protein phosphorylation
GO:0006605 protein targeting
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007268 synaptic transmission
GO:0015844 monoamine transport
GO:0021782 glial cell development
GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation
GO:0036294 cellular response to decreased oxygen levels
GO:0042149 cellular response to glucose starvation
GO:0043045 DNA methylation involved in embryo development
GO:0043046 DNA methylation involved in gamete generation
GO:0043113 receptor clustering
GO:0045161 neuronal ion channel clustering
GO:0060292 long term synaptic depression
GO:0097061 dendritic spine organization
GO:0097062 dendritic spine maintenance
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
GO:0030054 cell junction
GO:0030666 endocytic vesicle membrane
GO:0042734 presynaptic membrane
GO:0043005 neuron projection
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0048471 perinuclear region of cytoplasm
GO:0097481 neuronal postsynaptic density
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000068206
View Gene Order
ENSBTAG00000015268
Not yet available
Pathways
NETPATH
REACTOME
REACT_18422
Trafficking of GluR2-containing AMPA receptors pathway
REACT_18307
Trafficking of AMPA receptors pathway
REACT_13685
Neuronal System pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_18347
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F6TII1 F6V107 F6VY12
UniProt Splice Variant
Entrez Gene 9463
UniGene Hs.180871 Hs.742009
RefSeq NM_001039583 NM_001039584 NM_012407
HUGO HGNC:9394
OMIM 605926
CCDS CCDS13965
HPRD 16176
IMGT
EMBL AL031587
GenPept
RNA Seq Atlas 9463

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca