Version 5.4
Homo sapiens Protein: MTA3
Summary
InnateDB Protein IDBP-293821.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MTA3
Protein Name metastasis associated 1 family, member 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000385045
InnateDB Gene IDBG-48544 (MTA3)
Protein Structure
UniProt Annotation
Function Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6. {ECO:0000269PubMed:12705869, ECO:0000269PubMed:15454082}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00512, ECO:0000255PROSITE-ProRule:PRU00624, ECO:0000269PubMed:12705869}.
Disease Associations
Tissue Specificity Expressed in germinal centers of lymphoid tissues. No expression in nonepithelial cells. {ECO:0000269PubMed:12705869}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 45 [view]
Protein-Protein 44 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR000679 Zinc finger, GATA-type
IPR000949 ELM2 domain
IPR001005 SANT/Myb domain
IPR001025 Bromo adjacent homology (BAH) domain
IPR009057 Homeodomain-like
PFAM PF00320
PF01448
PF00249
PF01426
PRINTS PR00619
PIRSF
SMART SM00401
SM00717
SM00439
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BTC8
PhosphoSite PhosphoSite-Q9BTC8
TrEMBL Q53SC0
UniProt Splice Variant
Entrez Gene 57504
UniGene Hs.743512
RefSeq NP_065795
HUGO HGNC:23784
OMIM 609050
CCDS CCDS46267
HPRD 12359
IMGT
EMBL AB033092 AC025750 AC074375 AC098824 AK027304 AL161954 BC004227 BC053631
GenPept AAH04227 AAH53631 AAY14699 AAY24040 AAY24110 BAA86580 BAB55028 CAB82305

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca