InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC8A1

Summary

InnateDB Protein

IDBP-293863.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC8A1

Protein Name

solute carrier family 8 (sodium/calcium exchanger), member 1

Synonyms

NCX1;

Species

Homo sapiens

Ensembl Protein

ENSP00000385188

InnateDB Gene

IDBG-47824 (SLC8A1)

Protein Structure

UniProt Annotation

Function

Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores. {ECO:0000269PubMed:1476165}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in cardiac sarcolemma, brain, kidney, liver, pancreas, skeletal muscle, placenta and lung. {ECO:0000269PubMed:1476165}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005432	calcium:sodium antiporter activity
GO:0005516	calmodulin binding
GO:0008092	cytoskeletal protein binding
GO:0030506	ankyrin binding
GO:0044325	ion channel binding
GO:0046872	metal ion binding

Biological Process

GO:0002026	regulation of the force of heart contraction
GO:0002027	regulation of heart rate
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0006936	muscle contraction
GO:0007154	cell communication
GO:0007596	blood coagulation
GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0014829	vascular smooth muscle contraction
GO:0034614	cellular response to reactive oxygen species
GO:0035725	sodium ion transmembrane transport
GO:0044557	relaxation of smooth muscle
GO:0051481	negative regulation of cytosolic calcium ion concentration
GO:0055013	cardiac muscle cell development
GO:0055074	calcium ion homeostasis
GO:0055085	transmembrane transport
GO:0055119	relaxation of cardiac muscle
GO:0060401	cytosolic calcium ion transport
GO:0060402	calcium ion transport into cytosol
GO:0070509	calcium ion import
GO:0071313	cellular response to caffeine
GO:0071436	sodium ion export
GO:0086064	cell communication by electrical coupling involved in cardiac conduction
GO:0097369	sodium ion import
GO:1901660	calcium ion export

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0014704	intercalated disc
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030018	Z disc
GO:0030315	T-tubule
GO:0042383	sarcolemma

Protein Structure and Domains

PDB ID

InterPro

IPR001623 DnaJ domain
IPR002987 Sodium/calcium exchanger, isoform 1
IPR003644 Na-Ca exchanger/integrin-beta4
IPR004836 Sodium/calcium exchanger protein
IPR004837 Sodium/calcium exchanger membrane region

PFAM

PF00226
PF03160
PF01699

PRINTS

PR00625
PR01260
PR01259

PIRSF

SMART

SM00271
SM00237

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt