InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TICRR

Summary

InnateDB Protein

IDBP-29399.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TICRR

Protein Name

chromosome 15 open reading frame 42

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000268138

InnateDB Gene

IDBG-29397 (TICRR)

Protein Structure

UniProt Annotation

Function

Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre- initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269PubMed:20116089}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:20080954}. Note=Associates with chromatin.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005515	protein binding

Biological Process

GO:0000075	cell cycle checkpoint
GO:0001731	formation of translation preinitiation complex
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0010212	response to ionizing radiation
GO:0030174	regulation of DNA-dependent DNA replication initiation
GO:0033314	mitotic DNA replication checkpoint