InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRPF40A

Summary

InnateDB Protein

IDBP-294012.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRPF40A

Protein Name

PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000386458

InnateDB Gene

IDBG-72518 (PRPF40A)

Protein Structure

UniProt Annotation

Function

Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing. {ECO:0000250, ECO:0000269PubMed:21834987}.

Subcellular Localization

Nucleus speckle {ECO:0000250}. Nucleus matrix {ECO:0000269PubMed:16391387}. Note=Colocalizes with AKAP8L in the nuclear matrix. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the brain cortex (at protein level). Widely expressed. {ECO:0000269PubMed:16391387, ECO:0000269PubMed:9700202}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 209 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	209 [view]
Protein-Protein	209 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0070064	proline-rich region binding

Biological Process

GO:0006397	mRNA processing
GO:0007010	cytoskeleton organization
GO:0007049	cell cycle
GO:0008360	regulation of cell shape
GO:0008380	RNA splicing
GO:0016477	cell migration
GO:0032465	regulation of cytokinesis
GO:0051301	cell division