InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KYNU

Summary

InnateDB Protein

IDBP-294122.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KYNU

Protein Name

kynureninase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000386731

InnateDB Gene

IDBG-71532 (KYNU)

Protein Structure

UniProt Annotation

Function

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.

Subcellular Localization

Cytoplasm {ECO:0000255HAMAP-Rule:MF_03017, ECO:0000269PubMed:8706755}.

Disease Associations

Note=Xanthurenic aciduria manifesting as massive urinary excretion of large amounts of kynurenine, 3-hydroxykynurenine and xanthurenic acid has been observed in an individual carrying a homozygous missense change in KYNU (PubMed:17334708). The urinary pattern in the patient suggests kynureninase deficiency and a block in the conversion of kynurenine and 3-hydroxykynurenine to anthranilate and 3-hydroxyanthranilate, respectively. {ECO:0000269PubMed:17334708}.

Tissue Specificity

Expressed in all tissues tested (heart, brain placenta, lung, liver, skeletal muscle, kidney and pancreas). Highest levels found in placenta, liver and lung. Expressed in all brain regions. {ECO:0000269PubMed:8706755, ECO:0000269PubMed:9180257}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	31 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0030170	pyridoxal phosphate binding
GO:0030429	kynureninase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0006569	tryptophan catabolic process
GO:0008152	metabolic process
GO:0009435	NAD biosynthetic process
GO:0019805	quinolinate biosynthetic process
GO:0034341	response to interferon-gamma
GO:0034354	'de novo' NAD biosynthetic process from tryptophan
GO:0034516	response to vitamin B6
GO:0034641	cellular nitrogen compound metabolic process
GO:0043420	anthranilate metabolic process
GO:0044281	small molecule metabolic process
GO:0097053	L-kynurenine catabolic process