InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LTBP1

Summary

InnateDB Protein

IDBP-294142.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LTBP1

Protein Name

latent transforming growth factor beta binding protein 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000386043

InnateDB Gene

IDBG-43767 (LTBP1)

Protein Structure

UniProt Annotation

Function

May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extra cellular matrix (ECM).

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Isoform Long is found in fibroblasts.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005024	transforming growth factor beta-activated receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0050431	transforming growth factor beta binding

Biological Process

GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0030198	extracellular matrix organization
GO:0035583	sequestering of TGFbeta in extracellular matrix