Version 5.4
Homo sapiens Gene: LTBP1
Summary
InnateDB Gene IDBG-43767.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LTBP1
Gene Name latent transforming growth factor beta binding protein 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000049323
Encoded Proteins
IDBP-294142
latent transforming growth factor beta binding protein 1
IDBP-294144
latent transforming growth factor beta binding protein 1
IDBP-294140
latent transforming growth factor beta binding protein 1
IDBP-294135
latent transforming growth factor beta binding protein 1
IDBP-372128
latent transforming growth factor beta binding protein 1
IDBP-372140
latent transforming growth factor beta binding protein 1
IDBP-372145
latent transforming growth factor beta binding protein 1
IDBP-372146
latent transforming growth factor beta binding protein 1
IDBP-372148
latent transforming growth factor beta binding protein 1
IDBP-480844
latent transforming growth factor beta binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:32946972-33399509
Strand Forward strand
Band p22.3
Transcripts
ENST00000404816 ENSP00000386043
ENST00000402934 ENSP00000384373
ENST00000404525 ENSP00000385359
ENST00000407925 ENSP00000384091
ENST00000432635 ENSP00000405993
ENST00000418533 ENSP00000393057
ENST00000413303 ENSP00000415412
ENST00000415140 ENSP00000388154
ENST00000422669 ENSP00000395211
ENST00000468091 ENSP00000417591
ENST00000498013
ENST00000489740
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005024 transforming growth factor beta-activated receptor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0050431 transforming growth factor beta binding
Biological Process
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0030198 extracellular matrix organization
GO:0035583 sequestering of TGFbeta in extracellular matrix
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0031012 extracellular matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001870
View Gene Order
ENSBTAG00000019839
Not yet available
Pathways
NETPATH
REACTOME
REACT_150331
Molecules associated with elastic fibres pathway
REACT_150366
Elastic fibre formation pathway
REACT_118779
Extracellular matrix organization pathway
KEGG
hsa04350
TGF-beta signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.619315
RefSeq NM_000627 NM_001166264 NM_001166265 NM_001166266 NM_206943 XM_005264315 XM_005264317 XM_005264319 XM_006712019
HUGO
OMIM
CCDS CCDS33177 CCDS33178 CCDS54344 CCDS54345
HPRD 01039
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca