InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARHGAP35

Summary

InnateDB Protein

IDBP-294162.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGAP35

Protein Name

Rho GTPase activating protein 35

Synonyms

GRF-1; GRLF1; P190-A; P190A; p190ARhoGAP; p190RhoGAP;

Species

Homo sapiens

Ensembl Protein

ENSP00000385720

InnateDB Gene

IDBG-59119 (ARHGAP35)

Protein Structure

UniProt Annotation

Function

Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'- GAGAAAAGAAACTGGAGAAACTC-3'. May participate in the regulation of retinal development and degeneration. May transduce signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP). May also act as a tumor suppressor. {ECO:0000269PubMed:1894621}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0005100	Rho GTPase activator activity
GO:0005525	GTP binding

Biological Process

GO:0001843	neural tube closure
GO:0006351	transcription, DNA-templated
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007411	axon guidance
GO:0008360	regulation of cell shape
GO:0030900	forebrain development
GO:0032321	positive regulation of Rho GTPase activity
GO:0043010	camera-type eye development
GO:0043116	negative regulation of vascular permeability
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0015629	actin cytoskeleton

Protein Structure and Domains

PDB ID

InterPro

IPR000198 Rho GTPase-activating protein domain
IPR001806 Small GTPase superfamily
IPR002713 FF domain
IPR008936 Rho GTPase activation protein
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00620
PF00071
PF01846

PRINTS

PR00449

PIRSF

SMART

SM00324
SM00441

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt