InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ARHGAP35

Summary

InnateDB Gene

IDBG-59119.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGAP35

Gene Name

Rho GTPase activating protein 35

Synonyms

GRF-1; GRLF1; P190-A; P190A; p190ARhoGAP; p190RhoGAP

Species

Homo sapiens

Ensembl Gene

ENSG00000160007

Encoded Proteins

IDBP-294162

Rho GTPase activating protein 35

IDBP-813264

Rho GTPase activating protein 35

IDBP-813266

Rho GTPase activating protein 35

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:46918676-47005077

Strand

Forward strand

Band

q13.32

Transcripts

ENST00000404338	ENSP00000385720
ENST00000596593
ENST00000598548
ENST00000595822
ENST00000599284
ENST00000614079	ENSP00000483730
ENST00000615647	ENSP00000479487

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0005100	Rho GTPase activator activity
GO:0005525	GTP binding

Biological Process

GO:0001843	neural tube closure
GO:0006351	transcription, DNA-templated
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007411	axon guidance
GO:0008360	regulation of cell shape
GO:0030900	forebrain development
GO:0032321	positive regulation of Rho GTPase activity
GO:0043010	camera-type eye development
GO:0043116	negative regulation of vascular permeability
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051056	regulation of small GTPase mediated signal transduction